Millennium Pharmaceuticals Limited

Cor Therapeutics, Inc.

Wenrong Huang

Bing-Yan Zhu

Robert M Scarborough

Penglie Zhang

Yonghong Song

Erick A Goldman

Lingyan Wang

Wenhao Li

Jingmei Zuckett

Zhaozhong Jon Jia

James P Kanter

Shawn M Bauer

Robert M Scarborough, Deceased

John Woolfrey

Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

Benzamides and related inhibitors of factor Xa

Benzamides and related inhibitors of factor XA

Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compound and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Benzamide inhibitors of factor Xa

Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Thioether-substituted benzamide compounds having the formula:are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.

Thioether-substituted benzamides as inhibitors of Factor Xa

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Cupertino, CA, United States of America

Wenrong Huang