Zhejiang Huahai Pharmaceutical Co., Ltd.

Zhejiang Huahai Zhicheng Pharmaceutical Co., Ltd

Wenquan Zhu

Jinsheng Lin

Min Li

Dan Li

Tianpei Huang

Wenbin Chen

Peng Wang

Jing Wang

Zhiyun Wang

Peng Dong

Xiaoyan Xu

Yue Li

Hong Cai

Tong Wu

Qiang Zhou

Yuanxun Zhu

Libin Hu

Danfeng Ye

Tan Xiao

Feifei Lan

Xiaoren Zhu

Xiaohui Zhou

Xiaofei Liu

Provided are a pregabalin lactam methylene dimer and a preparation method therefor. The method comprises the following steps: dissolving pregabalin in a reaction solvent, reacting same with an aldehyde in an acidic system and isolating the obtained target product pregabalin lactam methylene dimer. The preparation method for pregabalin lactam methylene dimer provided by the present application has a simple operation, a high product yield, a good purity and a low cost.

Pregabalin lactam methylene dimer and preparation method therefor

Disclosed is N-formyl vortioxetine, and also disclosed is a method for preparing the N-formyl vortioxetine and a stable solid preparation of vortioxetine.

N-formyl vortioxetine and preparation method thereof and solid preparation of vortioxetine

Disclosed is a detection method for N-nitrosodimethylamine (NDMA) impurities, comprising: (1) obtaining a test solution containing a sample to be tested; and (2) detecting the test solution by means of gas chromatography-mass spectrometry to determine the content of an N-nitrosodimethylamine impurity in the sample. The method provided in the present invention has a good separating effect, a wide linear range, a high sensitivity and a good method durability, and can detect the content of N-nitrosodimethylamine (NDMA) in the sample rapidly and effectively.

Detection method for n-nitrosodimethylamine impurities

A method for synthesizing valsartan, comprising the steps of: synthesizing a valsartan methyl ester intermediate to obtain a reaction mixture of the valsartan methyl ester intermediate; diluting the reaction mixture by salt water or water, and then using a first extraction solvent to extract the valsartan methyl ester intermediate; adding alkali to an organic layer containing the valsartan methyl ester intermediate for hydrolyzing, removing the organic layer, regulating pH of a water layer to be acidic by using acid, using the first extraction solvent to extract, concentrating a part of solvent, or distilling the solvent to dryness, and then adding a new solvent; finally, crystallizing, filtering, and drying to obtain the valsartan.

Method for synthesizing valsartan

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Taizhou, China

Wenquan Zhu