Lifecell Corporation

Wenquan Sun

Hui Xu

Hua Wan

Gary Monteiro

Rick T Owens

Mark Hayzlett

Yi Heng Chen

Dennis Lee

Kai-Roy Wang

Melissa Richter Bowley

Li Ting Huang

Matthew F Amato

Timothy Roock

Nimesh Kabaria

Raymond Hull

Xiaohua Yu

Heather Ansorge

Xianghong Liu

Michael Taenzer

Lawrence Lapitan

Raghav Goel

Nathaniel Bachrach

Patrick Leamy

Yi Chen

Xiaohura Yu

Mark R Hayzlett

Improved prostheses comprising a tissue expander and a graft material are disclosed herein. Also disclosed are methods of making prostheses and methods of treatment using the prostheses.

Implantable prosthesis having acellular tissue attachments

Methods of making tissue fillers are provided. In certain embodiments, the tissue is flake-like and has regenerative properties.

Regenerative materials

The present disclosure provides tissue products produced from adipose-containing tissues, as well as methods for producing such tissue products. The tissue products can include decellularized and partially de-fatted tissues. In addition, the present disclosure provides systems and methods for using such products.

Processed adipose tissue

Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include acellular arterial tissue matrices that facilitate regrowth of the damaged tissue.

Device for tendon and ligament treatment

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

Natural tissue scaffolds as tissue fillers

Devices and methods for treating an abdominal incision or hernia are described. An implant for the restoration or prophylactic treatment of an abdominal wall comprises an elongate element and at least one sheet connected to the elongate element along a longitudinal axis of the elongate element. The elongate element is positioned along the line of incision, and the at least one sheet is secured to the abdominal muscles surrounding the incision.

Device and method for treatment of incision or hernia

Disclosed herein are tissue-based drain manifolds comprising partially or completely decellularized tissue that has been processed to form tubes, columns, sheets, or other shapes and which are useful for managing the drainage of fluid and/or the administration of negative pressure at an implant site in a patient. The manifolds can be implanted in a patient and provide a natural scaffold in which native cells from surrounding tissue can migrate and proliferate, thereby avoiding the need to remove the implanted manifolds after drainage is complete.

Tissue-based drain manifolds

Disclosed herein are flowable tissue matrix compositions comprising small pieces of partially or completely decellularized tissue suspended in a gelatinized tissue or gelatin gel comprising partially or completely decellularized tissue or synthetic gelatin. The flowable tissue matrix compositions can contain factors that promote or enhance native cell migration, proliferation, and/or revascularization after implantation into a subject. Also disclosed are methods of making and using the flowable tissue matrix compositions. The compositions can be implanted into a tissue in need of repair, regeneration, healing, treatment, and/or alteration, and can promote or enhance native cell migration, proliferation, and/or revascularization.

Flowable tissue matrices

Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include enzyme-activated acellular tissue matrices that facilitate regrowth of the damaged tissue.

Enzyme-activated collagen and tissue matrices

A tissue-derived hydrogel, as well as methods of making and using such hydrogels, are provided.

Elastic tissue matrix derived hydrogel

A prosthesis comprising a tissue expander and one or more samples of graft material, wherein the tissue expander is attached to the one or more samples of graft material in a manner that allows the tissue expander and the one or more samples of graft material to be implanted in a patient as a unitary prosthesis; and wherein tissue expander is attached to the one or more samples of graft material in a manner that will allow the tissue expander and the graft material to separate after a period of time following implantation to allow removal of the tissue expander from an implant sites while leaving the graft material within the implant site, the prosthesis comprises a tissue expander having molded grooves, slots, channels, or other shallow cavity spaces on a surface, and wherein the graft material is within the grooves, slots, channels, or other shallow cavity spaces, securing the graft material to the tissue expander.

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.

Growing community of inventors

Warrington, PA, United States of America

Wenquan Sun