Telik, Inc.

Sanwa Kagaku Kenkyusho Co., Ltd.

Wenli Ma

Kevin T Weber

Edgardo Laborde

Louise Robinson

Brian T Peterson

Kouji Matsushima

Songyuan Shi

Steven R Schow

Hugo O Villar

Yoshiro Ishiwata

Yukiharu Matsumoto

Shoji Yokochi

Reyna J Simon

Michael M Wick

Fanying Meng

Steven E Anuskiewicz

Hideaki Inagaki

Paul Beroza

Andrew B Kelson

Mitsuaki Takeuchi

Komath V Damodaran

Hua Xu

Robert Yee

David R Allen

Stella Lui

Zhuo Wang

Kunihisa Baba

Katsumasa Tanaka

Masayuki Okamoto

Takashi Nakamura

Atsushi Miyachi

Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.

Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors

Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.

Sulfonylethyl phosphorodiamidates

2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.

2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates

2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N',N&#x2032;-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.

2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates

Compounds of formula A and formula B:and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The compounds are antagonists of MCP-1 function, and are useful in the prevention and treatment of chronic or acute inflammatory or autoimmune diseases, such as multiple sclerosis, and in the prevention and treatment of allergic hypersensitivity disorders.

Antagonist of MCP-1 function, and compositions and methods of use thereof

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Union City, CA, United States of America

Wenli Ma