The Hong Kong University of Science and Technology

Southern Marine Science and Engineering Guangdong Laboratory (guangzhou)

Wenkang Ye

Aifang Cheng

Peiyuan Qian

Guang Zhu

Changdong Liu

Pei-Yuan Qian

Jinping Cheng

Ruojun Wang

Chunfeng Ma

Weiyi She

The present invention provides potent antibiofilm and antifouling compounds albofungin and derivatives thereof isolated fromBCC 24770, the construction of high-yield strains for albofungin production, and application of albofungin-based copolymer coatings to object or surfaces, particularly to inhibit fouling by marine organisms using hydrolysable and degradable antifouling coatings incorporated with albofungins.

Potent antifouling agents albofungins target multiple fouling organisms

The subject invention pertains to compositions and methods for treating neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis, epilepsy, stroke, alcohol withdrawal, progressive supranuclear palsy (PSP), Pick's disease (PiD), corticobasal degeneration (CBD), frontotemporal dementia or parkinsonism linked to chromosome 17 (FTDP-17). The methods of the subject invention further relate to methods of fermentation of bacterial cells and methods of tautomerization of the subject compounds.

Compounds as potential therapeutic agents targeting various neurodegenerative diseases

The subject invention pertains to compositions comprising albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo. The subject invention further pertains to methods of treating a subject with HIV using albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo.

Albofungin and its derivatives specifically recognize HIV-1 LTR-III G-quadruplex

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Hong Kong, China

Wenkang Ye