Life Technologies Corporation

Dana-farber-cancer Institute Inc.

Gatekeeper Pharmaceuticals, Inc.

Wenjun Zhou

Kyle R Gee

Nathanael Schiander Gray

Hee Chol Kang

Shih-Jung Huang

Hwan Geun Choi

Shaheer Khan

Jae Won Chang

Aleksey Rukavishnikov

Jianming Zhang

Taebo Sim

Daniel Beacham

Brian Lee Evans

Upinder Singh

Michael O'Grady

James Stray

Michael Wayne Olszowy

Peter Slade

Ellen Weisberg

Michael Janes

Yolanda Tennico

Bradley Dubbels

Pasi Antero Janne

Xianming Deng

Nathanael S Gray

Michael Eck

Monica Tomaszewski

Penny Melquist

Michael J Eck

Michael Olszowy

Judith Berlier

Provided herein are compounds, enzyme substrates, compositions, kits, uses, and methods for detecting the presence or absence of a caspase enzyme, measuring the activity of a caspase enzyme, or detecting the presence or absence of apoptosis. The detection or measurement can occur through intracellular cleavage of a compound or enzyme substrate, which can lead to an increase in fluorescence, e.g., in the violet or red channel, through liberation of a nucleic acid binding dye from a peptide, such as liberation of a DNA-binding dye from a negatively charged peptide comprising a sequence recognized and cleaved by a caspase.

Methods and compositions for detecting or measuring caspases or apoptosis

The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

Hydrazinyl and aminooxy compounds and their methods of use

Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.

Carbopyronone compounds useful as diagnostic adjuvants

Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.

Fluorogenic pH-sensitive dyes and their methods of use (II)

The present invention relates to novel pyrimidine, pyrrolo-pyrimidine, pyrrolo-pyridine, pyridine, purine and triazine compounds which are able to modulate epidermal growth factor receptor (EGFR), including Her-kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.

EGFR inhibitors and methods of treating disorders

Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.

Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith

The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.

Fused 2-aminothiazole compounds

Indazole compounds and their uses

The present application relates to therapeutic organic compounds of formula (I), wherein Q, R1, R2, R3, and R4 are defined herein. The invention also relates to pharmaceutical compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease such as cancer comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.

Growing community of inventors

Eugene, OR, United States of America

Wenjun Zhou