Ventana Medical Systems, Inc.

Heraeus Gmbh

The Johns Hopkins University

Memorial Sloan Kettering Cancer Center

Bison Therapeutics, Inc.

Wenjun Zhang

Lei Tang

Michael Patrick Farrell

Antony Hubbard

Brian Daniel Kelly

Jim F Martin

Thomas M Grogan

Donald D Johnson

Eric J May

Brian D Kelly

Taylor J Shingler

Tsu-Shuen Tsao

Hiro Nitta

Bernd Kunkel

Lidija Pestic-Dragovich

Michael Sandlin

Mehrnoush Khojasteh

Mike Farrell

Robert Anders

Xiangxue Wang

Luis Diaz

Tom Grogan

Tobin Jones

Donald Johnson

Hiroaki Nitta

Taylor Shingler

Lesli Baca Parkinson

A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.

Methods and systems for predicting response to PD-1 axis directed therapeutics

The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Multiplexed immunohistochemistry using recombinant antibodies with epitope tags

Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Single-stranded oligonucleotide probes for chromosome or gene copy enumeration

Polymers and conjugates comprising polymers are disclosed herein. In some embodiments, the conjugates disclosed are suitable for use as detection probes in immunohistochemical assays, including multiplex immunohistochemical assays.

Polymers and conjugates comprising the same

Novel multispecific antibody platform, multispecific antibodies and a method to make the antibodies is disclosed here. The CH3 domain harboring polypeptide chains of the Fc-regions are modified by increasing the positive charge of one chain and negative charge of another chain. Heterodimer formation in cotransfection with the modified chains is comparable to formation of wild type antibodies when same cell line is transfected with wild type polypeptides. Moreover, the modification provides a simple one step purification of the heterodimers.

Multispecific antibody platform and related methods

The present disclosure relates to systems and methods for analyzing chromosomal translocations, and in particular to analysis of chromosomal translocation by in situ hybridization.

Method of analyzing chromosomal inversions

A method of fabricating a sputter target comprises: homogenously blending a plurality of powders including at least a first powder and a second powder. The first powder is comprised of chromium (Cr), cobalt (Co), ruthenium (Ru), nickel (Ni), or iron (Fe). The second powder is comprised of boron (B), carbon (C), a nitrogen (N)-containing material, a boride, a carbide, a nitride, a silicide, an oxygen (O)-containing material or an oxide. The second powder has a particle size of between 0.01 microns and 50 microns. The method further comprises: canning the blended plurality of powders to form a substantially non-segregated encapsulated powdered material mix; pressing the encapsulated powdered material mix to form a billet; and machining the billet to form a sputter target.

Sputter target and method for fabricating sputter target including a plurality of materials

Spent sputtering targets are refurbished by filling the depleted region of the target with new sputter material using a hot isostatic pressing or HIP'ing technique.

Refurbishing spent sputtering targets

The present invention relates to a method of manufacturing sputtering targets doped with non-metal components including boron, carbon, nitrogen, oxygen and silicon. A powder process is utilized whereby alloyed powders, which contain non-metal elements of B/C/N/O/Si and non-metal containing phases of less than ten microns in microstructure, are blended, canned and subjected to hot isostatic press consolidation. The sputtering targets of the present invention avoid spitting problems during sputtering of the target material on a substrate.

Fabrication of B/C/N/O/Si doped sputtering targets

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Tucson, AZ, United States of America

Wenjun Zhang