Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Wenjun Geng

Xiquan Zhang

Ling Yang

Fei Liu

Rui Zhao

Shanchun Wang

Xunqiang Wang

Hongmei Gu

Yanlong Liu

Xiangjian Wang

Xinlu Li

Zhongnan Xu

Huihui Zhang

Shanliang Zhu

The present application relates to the field of medicine, and relates to crystals of quinoline derivatives, and in particular, to crystals of a quinoline derivative anhydride and a solvate, as well as a method for preparing the crystals, pharmaceutical compositions containing the crystals, and a use thereof in the field of medicine. The present application further provides a preparation method therefor, which has a high yield, has mild crystallization conditions, is suitable for industrial production, and may better meet the needs of the pharmaceutical industry.

Crystals of quinolone derivatives

Provided in the present invention are a use of quinoline derivatives for treating oesophageal cancer and a treatment method, a pharmaceutical composition and a kit thereof. The 1-[[[4-(4-fluoro-2-methyl-1H-indole-5-yl)oxy-6-methoxyquinoline-7-yl]oxy]methyl]cyclopropylamine provided by the present invention can effectively treat oesophageal cancer, and reduce the sum of the diameters of patient's target lesions.

Use of quinoline derivatives for treating oesophageal cancer and treatment method, pharmaceutical composition and kit thereof

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Lianyungang, China

Wenjun Geng