Zhejiang Hisun Pharmaceutical Co., Ltd.

Wenjian Qian

Taishan Hu

Lei Chen

Cheng Ye

Ying Li

Zhengzheng Shi

Chenli Guo

Yongping Lu

Sunli Yan

Panpan Zhang

The present invention relates to a piperazine amide derivative as represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, and use of same as a therapeutic agent, especially as a selective Rearranged During Transfection (RET) kinase inhibitor. Ring a, ring e, X, X, X, X, R, R, R, R, R, R, R, R, R, R, R, R, m and n have the same definitions as those in the specification.

Piperazine amide derivative, preparation method therefor, and use thereof in medicine

Indazole derivatives represented by formula (I) or stereoisomers, tautomers, and pharmaceutically acceptable salts thereof are provided. A preparation method of indazole derivatives represented by formula (I) and a method of use of the indazole derivatives as therapeutic agents is also provided. The indazole derivatives of formula (I) are especially useful as interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors

Indazole amine derivative, preparation method therefor and medical use thereof

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Zhejiang, China

Wenjian Qian