Astrazeneca Ab

Wenhua Xiao

Thomas Michael Bare

Rebecca Urbanek

Dean Brown

Megan Murphy

Gary Steelman

Carey Horchler

Christine Barlaam

Frances Marie McLaren

Edward Vacek

Vernon Alford

Compounds according to structural diagram (I) The following is an examiner's statement of reasons for allowance: In view of applicants' amendments to the claims which limit 'E' to phenyl or cycloalkyl groups the rejections of the previous action no longer pertain as they at best teach 'E' as alkyl.

1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain

A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino [4,5-b]quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.

Compound and method for the treatment of pain

A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, its (&#x2212;) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (&#x2212;) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (&#x2212;) enantiomer are disclosed.

7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain

Compounds useful for the treatment of pain in accord with structural diagram (I), or tautomers or pharmaceutically-acceptable salts of such compounds, wherein R and A are as disclosed in the specification. Also disclosed are methods for the treatment of pain using compounds according to structural diagram (I) and pharmaceutical compositions comprising compounds according to structural diagram (I).

1, 2, 5, 10-tetrahydropyridazino&lsqb;4, 5-b&rsqb;quinoline-1,10-diones and their use for the treatment of pain

A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino&lsqb;4,5-b&rsqb;quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.

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Wilmington, DE, United States of America

Wenhua Xiao