Halliburton Energy Services, Inc.

The Methodist Hospital

Wenhao Chen

Christopher A Golla

Randal Thomas Beste

Matthew Chase Griffing

Imran Sharif Vehra

Zinovy B Krugliak

Xian Chang Li

Rameez Balagamwala

Methods to treat cancer in a subject comprising administering to the subject a therapeutically effective amount of T-cells of the subject having increased IRF4 polypeptide expression compared to a control are disclosed. Also disclosed are methods of increasing tumor reactivity of a T-cell by increasing IRF4 polypeptide expression, and methods to predict the likelihood that a subject having cancer will respond therapeutically to administered T-cells having increased IRF4 polypeptide expression. Also disclosed are compositions comprising a T-cell and a viral vector encoding an IRF4 polypeptide. The compositions are methods are useful for treating numerous cancers in which higher level expression of IRF4 in T-cells would be beneficial. In some embodiments, activated tumor specific T-cells having increased IRF4 expression have greater infiltration in tumors and enhanced local immunological responses.

IRF-4 engineered T cells and uses thereof in treating cancer

A method for calibrating a downhole tool may comprise disposing a downhole tool in a borehole, transmitting a signal from a master module disposed on the first device to a module disposed on the second device, transmitting a return signal from the module to the master module, receiving the return signal with the master module, measuring a tone enabled delay for the signal to travel from the master module to the module, and determining a time delay of a return signal to travel from the module to the master module. A well measurement system may comprise a downhole tool. The downhole tool may further comprise a first device and a master module disposed on the first device, wherein the master module may comprise a master transmitter and a master receiver. In examples, the downhole tool may further comprise a second device and a module disposed on the second device.

Clock calibration of remote systems by roundtrip time

Growing community of inventors

Houston, TX, United States of America

Wenhao Chen