Pharmacopeia Inc.

Vitae Pharmaceuticals, Inc.

Pharmacopeia Drug Discovery, Inc.

Wenguang Zeng

John J Baldwin

Lawrence Wayne Dillard

Ge Li

John C Reader

David A Claremon

Jing Yuan

Zhenrong Xu

Alexey V Ishchenko

Jonathan J Burbaum

Gerard McGeehan

6-(Aminoalkyl)indazoles of formula (I) and the salts thereof have renin-inhibiting properties and can be used as antihypertensive, and renal, cardiac and vascular protecting medicinally active ingredients. 

6-(aminoalkyl)indazoles

Combinatorial dihydrobenzopyran library

Combinatorial libraries are disclosed which are represented by Formula I: ##STR1## wherein: ##STR2## is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula ##STR3## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.

Combinatorial libraries are disclosed which are represented by Formula I:

Process for preparing intermediates for a combinatorial

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Lawrenceville, NJ, United States of America

Wenguang Zeng