Boston Scientific Scimed, Inc.

Applied Materials, Inc.

Qualcomm Mems Technologies, Inc.

Psiquantum Corp.

Wenguang Li

James S Papanu

Anming He Cai

Ajay Kumar

Brad Eaton

Alexander N Lerner

Lewis Jones Thomas, Iii

Neil Pollock

Justin Michael Lerman

Gaylin Mildred Yee

Wei-Sheng Lei

Vimal Kumar Kamineni

Tat-Jin Teo

Prabhat Kumar

David Burgess

Qian Li

Mikhail E Bashtanov

Nathaniel Stark

Cory P Wright

Fahad Hussain

Mette Funding La Cour

Shashidhar Sathyanarayana

Gabriel J Mendoza

Corydon Carlson

Khanh Tran

Richard Romley

Ramesh Krishnamurthy

Tsongming Kao

Mark G Thompson

Jon M Knight

Kevin Bloms

Michael William Hansen

Matthew R Huston

Lewis Jones Iii Thomas

Lewis Jones Thomas Iii

An optical interposer can be formed from multiple wafers, including a photonic integrated circuit wafer and an interposer wafer. The photonic integrated circuit wafer can be bonded to a rigid carrier structure, and material near waveguides can be removed such that the waveguides can be coupled to waveguides of the interposer. The photonic integrated circuit can be separated into multiple rigid dies which can be bonded to the interposer separately. Additional processing can be performed to form electrical connections to the rigid dies to form an ultra-low optical interposer.

Low loss optical interposer

A method, device, and system for evaluating a vessel of a patient, and in particular the hemodynamic impact of a stenosis within the vessel of a patient. Proximal and distal pressure measurements are made using first and second instrument while the first instrument is moved longitudinally through the vessel from a first position to a second position and the second instrument remains in a fixed longitudinal position within the vessel. A series of pressure ratio values are calculated, and a pressure ratio curve is generated. One or more stepped change in the pressure ratio curve are then identified and/or located using an Automatic Step Detection (ASD) process and/or algorithm. The ASD includes identifying a general position of a starting point of the stepped change by identifying a change in the pressure ratio values within a first window along the pressure ratio curve that is at or above a first threshold change value, and identifying an optimized position of the starting point by identifying a change in the pressure ratio values within a second window along the pressure ratio curve that is at or above a second threshold change value, wherein the second window is smaller than the first window, and the second threshold change value is smaller than the first threshold change value.

Methods for assessing a vessel with sequential physiological measurements

Methods include capturing intravascular ultrasound images. A drive motor is used to actively drive an ultrasound transducer at a set rotation speed. A temporary sensing window is created in which the ultrasound transducer is driven with a fixed drive signal. A plurality of signals from are received the ultrasound transducer during the temporary sensing window.

Reducing catheter rotation motor PWM interference with intravascular ultrasound imaging

A method, device, and system for evaluating a vessel of a patient, and in particular the hemodynamic impact of a stenosis within the vessel of a patient. Proximal and distal pressure measurements are made using first and second instrument while the first instrument is moved longitudinally in the vessel and the second instrument remains in a fixed position. A series of pressure ratio values are calculated, and a pressure ratio curve is generated. The pressure ratio curve may be output to a display. One or more stepped change in the pressure ratio curve are identified using an Automatic Step Detection algorithm. An image is obtained showing the position of the first instrument within the vessel that corresponds to the identified stepped change. The image is registered to the identified stepped change in the pressure ratio curve. The image may be output to the display.

This disclosure provides alternative medical imaging systems and methods for vascular imaging co-registration. Methods include obtaining extravascular imaging data of a portion of a blood vessel including an extravascular image showing an intravascular imaging device disposed within the vessel with an imaging element disposed at a starting location for a translation procedure. The extravascular image also includes an extravascular contrast image showing the portion of the blood vessel with contrast showing a visualized anatomical landmark. Intravascular imaging data is obtained during the translation procedure that includes one or more intravascular images showing a detected anatomical landmark. The starting location and the ending location of the imaging element on the extravascular imaging data is marked, and the predicted location of the detected anatomical landmark on the extravascular imaging data is marked. The predicted location of the detected anatomical landmark is then aligned with the visualized anatomical landmark.

Systems and methods for vascular image co-registration

Pressure sensing guidewires and methods for making and using pressure sensing guidewires are disclosed. An example pressure sensing guidewire may include a tubular member having a proximal region and a housing region. An optical pressure sensor may be disposed within the housing region. The optical pressure sensor may include a sensor body and a deflectable membrane coupled to the sensor body. The deflectable membrane may include a polymer. An optical fiber may be coupled to the sensor body and may extend proximally therefrom. A pressure equalization channel is formed in the optical fiber, the sensor body, or both.

Medical device with pressure sensor

Water soluble organic-inorganic hybrid masks and mask formulations, and methods of dicing semiconductor wafers are described. In an example, a mask for a wafer singulation process includes a water-soluble matrix based on a solid component and water. A p-block metal compound, an s-block metal compound, or a transition metal compound is dissolved throughout the water-soluble matrix.

Water soluble organic-inorganic hybrid mask formulations and their applications

Systems for determining fractional flow reserve are disclosed. An example system may include a pressure sensing guidewire for measuring a first pressure, a second pressure sensing medical device for measuring a second pressure, and a processor coupled to the pressure sensing guidewire and coupled to the second pressure sensing medical device. The processor may be designed to generate a plot of the magnitude of the second pressure over time, identify one or more time intervals of the plot that have a slope less than zero, determine a mean of the second pressure, and calculate the ratio of the first pressure to the second pressure when (a) the second pressure is less than or equal to the mean of the second pressure and (b) during the one or more time intervals when the slope of the plot is less than zero.

Methods for assessing fractional flow reserve

Pressure sensing guidewires and methods for making and using pressure sensing guidewires are disclosed. An example pressure sensing guidewire may include a tubular member having a proximal region and a housing region. An optical fiber may be disposed within the tubular member and extend to the housing region. The optical fiber may have a distal end region with a cavity formed therein. A polymeric member disposed within the cavity. A reflective surface disposed along the polymeric member.

Light-absorbing masks and methods of dicing semiconductor wafers are described. In an example, a method of dicing a semiconductor wafer including a plurality of integrated circuits involves forming a mask above the semiconductor wafer. The mask includes a water-soluble matrix based on a solid component and water, and a light-absorber species throughout the water-soluble matrix. The mask and a portion of the semiconductor wafer are patterned with a laser scribing process to provide a patterned mask with gaps and corresponding trenches in the semiconductor wafer in regions between the integrated circuits. The semiconductor wafer is plasma etched through the gaps in the patterned mask to extend the trenches and to singulate the integrated circuits. The patterned mask protects the integrated circuits during the plasma etching.

Light-absorbing mask for hybrid laser scribing and plasma etch wafer singulation process

A method for real-time displaying of cross-sectional images during an intravascular ultrasound (IVUS) imaging procedure includes, during an intravascular ultrasound imaging procedure, receiving electrical signals from at least one transducer in a catheter as the at least one transducer rotates and moves longitudinally along a lumen of a patient blood vessel; during the intravascular ultrasound imaging procedure, processing the received electrical signals to form a series of cross-sectional images that are longitudinally-offset from one another along a length of the lumen; during the intravascular ultrasound imaging procedure, concurrently displaying i) a most recent image and ii) a previous image that is either a) selected by the operator or b) automatically selected as having a maximum or minimum of a selected image characteristic; and, during the intravascular ultrasound imaging procedure, updating the display of the most recent image as a new image from the series of cross-sectional images is processed.

Systems and methods for selection and displaying of images using an intravascular ultrasound imaging system

Etch masks and methods of dicing semiconductor wafers are described. In an example, an etch mask for a wafer singulation process includes a water-soluble matrix based on a solid component and water. The etch mask also includes a plurality of particles dispersed throughout the water-soluble matrix. The plurality of particles has an average diameter approximately in the range of 5-100 nanometers. A ratio of weight % of the solid component to weight % of the plurality of particles is approximately in the range of 1:0.1-1:4.

Etch mask for hybrid laser scribing and plasma etch wafer singulation process

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Santa Clara, CA, United States of America

Wenguang Li