Other

Wyeth

Dana-farber-cancer Institute Inc.

Millennium Pharmaceuticals Limited

Wengian An

Kenneth Rhodes

Huai-Ping Ling

Maria Betty

Ellis L Reinherz

Jing Li

Kazuhisa Nishizawa

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Potassium channel interacting polypeptides and uses thereof

A human CD2 cytoplasmic tail binding protein, CD2BP1, is described, as well as the nucleic acids encoding the protein. Also described are expression vectors and recombinant host cells comprising nucleic acids encoding the CD2BP1 protein, and methods of use for the CD2BP1 protein and nucleic acids encoding the CD2BP1 protein.

Cloning and characterization of a cdc15-like adaptor protein (CD2BP1)

Potassium channel interactors and uses therefor

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Framingham, MA, United States of America

Wengian An