Glympse Bio, Inc.

Droplet Biosciences, Inc.

Sunbird Bio, Inc.

Wendy Winckler Adamovich

Robert Samuel Langer

Sophie Cazanave

Mehar Cheema

Faycal Touti

Megan Elisabeth Long

Seka Lazare

Damion L Whitfield

The present application provides compositions and methods for determining a disease or condition in a subject. The method comprises contacting a body fluid with a molecule comprising a reporter thereof and the reported is cleaved by an agent in the body fluid. Diseases and conditions that can be determined by the method are also described.

Ex vivo protease activity detection for disease detection/diagnostic, staging, monitoring and treatment

The present invention provides methods for using drain fluid obtained from medical procedures to assess diagnostic biomarkers indicative of disease obtained from drain fluid. In some embodiments, the diagnostics biomarkers are cell-free nucleic acids. In some embodiments, the disease is cancer. In some embodiments, a library of cfDNA is prepared and/or sequenced. In some embodiments, the methods comprise extracting nucleic acid from surgical drain fluid; conducting a size selection procedure to isolate cell-free nucleic acid from the surgical drain fluid; and detecting the cell-free nucleic acid.

Methods for diagnosing and assessing disease using drain fluid

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Melrose, MA, United States of America

Wendy Winckler Adamovich