Harvard College

Compagnie Gervais Danone

Cornell University

Wendy Sarah Garrett

Laurie H Glimcher

Patrick Veiga

Patrick M Smith

Peggy Garault

Isabelle Chambaud

Johan Van Hylckama Vlieg

Artem Khlebnikov

Sonia Arora Ballal

Gaëlle Quéré

Disclosed herein are compositions and methods for providing an antioxidant effect to a subject, e.g., modulating or otherwise improving oxidative stress pathways and/or neutralizing or reducing damaging reactive oxygen species (ROS).

Leveraging oxidative stress pathways in lactic acid bacteria to promote gut homeostasis

Disclosed herein are compositions and methods that are useful for inducing the development of regulatory T cells (T). Such compositions and methods are useful for treating inflammatory conditions and in particular inflammatory conditions affecting the gastrointestinal tract of a subject. In certain embodiments, the present inventions generally relate to short chain fatty acids and the discovery that such short chain fatty acids may be used to treat and/or prevent inflammatory conditions by enhancing the size and immune function of a subject's endogenous Tpopulation.

Modulation of regulatory T cells via G-coupled protein receptor 43

Method of increasing the quantity of colonic T regulatory cells via G-coupled protein receptor 43

The present invention relates to a method for the prevention, treatment and reduction of gastro-intestinal inflammation in a subject by administering a specificbacteria, in particular a fermented dairy product comprising said specificbacteria for the prevention, treatment and reduction of gastro-intestinal inflammation, in particular for the prevention and treatment of inflammatory bowel disease (IBD), ulcerative colitis (UC) and/or Crohn's Disease (CD) and for the prevention and treatment of Irritable Bowel Syndrome (IBS).

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The instant invention is based, at least in part, on the discovery that T-bet maintains host commensal relationships in the gastrointestinal tract. Accordingly, this invention provides methods of treating and/or preventing ulcerative colitis, and/or colon cancer, and/or preventing colonization of a subject's gastrointestinal tract with commensal bacteria that promote ulcerative colitis as well as methods of identifying agents that treat and prevent the same.

Compositions and methods for the treatment and prevention of ulcerative colitis and colon cancer and screening methods to identify same

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Brookline, MA, United States of America

Wendy Sarah Garrett