Genentech, Inc.

Genetech, Inc.

Wendy N Sandoval

Michael Patrick Dillon

Paul J Carter

Richard L Vandlen

Christoph Spiess

Yiyuan Yin

Jianhui Zhou

Jacob Corn

Jennie Lill

David P Arnott

Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Multispecific antigen-binding proteins

Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry.

Microwave assisted deglycosylation of proteins for molecular weight determination by mass spectrometry

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San Francisco, CA, United States of America

Wendy N Sandoval