Battelle Memorial Institute

Micell Technologies, Inc.

Wendy J Shaw

James B McClain

John L Fulton

Clement R Yonker

Barbara J Tarasevich

Dean W Matson

Doug Taylor

George S Deverman

C Douglas Taylor

Leonard S Fifield

Krys Wallace

James Mcclain

A system and method are disclosed for coating surfaces of expandable medical devices with composite coatings. Coatings are composed of various materials including, e.g., polymers and drugs. Transfer of the coatings within a patient or other host forms a drug-eluting coating that delivers time-released drugs over time for treatment of a medical condition.

System and process for formation of a time-released, drug-eluting transferable coating

A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

Medical implants and methods of making medical implants

Growing community of inventors

Richland, WA, United States of America

Wendy J Shaw