Massachusetts Institute of Technology

Cabot Corporation

Therics, Inc.

Michael J. Cima

Wendy E. Pryce Lewis

Charles William Rowe

Peter A. Materna

Wendy E Pryce Lewis

Michael John Cima

Peter A Materna

Susnata Samanta

Peter F Pescatore

Michael J Cima

Chitrabala Subramanian

Rajendran R Chary

A self-supporting aerogel structure is provided. The structure comprises a plurality of aerogel particles adhered together with an adhesive to produce a material exhibiting low heat transfer and high transmission of visible light. The aerogel particles can be coated with a polymer or pre-polymer and remain free flowing until they are activated to complete polymerization.

Self supporting areogel insulation

A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.

System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form

System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form

The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.

System for manufacturing controlled release dosage forms, such as zero-order release profile dosage form manufactured by three-dimensional printing

System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing

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Lexington, MA, United States of America

Wendy E Pryce Lewis