Pacesetter, Inc.

Other

St. Jude Medical, Cardiology Division, Inc.

Pacestter, Inc.

Paceetter, Inc.

Wenbo Hou

Stuart Rosenberg

Michael Xiaoxuan Yang

Allen J Keel

Kyungmoo Ryu

Edward Karst

Xiaoyi Min

Kjell Noren

Steve Koh

Brian Jeffrey Wenzel

Gene A Bornzin

Taraneh Ghaffari Farazi

Timothy A Fayram

Thao Thu Nguyen

Bruce A Morley

Sheldon Williams

Riddhi Shah

Rupinder Bharmi

Kritika Gupta

Melanie Goodman Keiser

Laurence S Sloman

Kevin L Morgan

Thao T Ngo

Jong Gill

Steven Roger Conger

Anna Barlow

Fujian Qu

Kjell Norén

Ryan Rooke

Tracee E Eidenschink

Paul A Levine

Euljoon Park

Yelena Nabutovsky

Eric Steven Fain

Zoltan Somogyi

Michael E Benser

Armando M Cappa

Tejpal Singh

Chunlan Jiang

Alex C Soriano

Alexander Kent

Greg Kampa

Julie Prillinger

Mitch Goodman

Caroline D Jordan

Ryan Bennett Sefkow

John VanScoy

Li Jin

Risshi Shah

Jake Singer

Craig D Markovitz

Systems and methods are provided for implanting an implantable cardiac monitor. An insertion system includes an implantable cardiac monitor (ICM). An insertion housing comprises a passage extending from a first end of the insertion housing to a second end of the insertion housing. The passage configured to receive the obturator and a receptacle in communication with the passage and an external environment. The receptacle configured to receive the ICM. An obturator is configured to move within the passage when the obturator is moved relative to the insertion housing. The obturator has a channel forming section at a distal end thereof and a motion limiter is provided on at least one of the shaft and the insertion housing.

Systems and methods for implanting an implantable cardiac monitor

System and methods are provided for determining a stimulation threshold for closed loop spinal cord stimulation (SCS). The system and methods provide a lead coupled to an implantable pulse generator (IPG). The system and methods deliver SCS pulses from the IPG to the lead electrodes in accordance with an SCS therapy and determine an evoked compound action potential (ECAP) amplitude based on an ECAP waveform resulting from the SCS therapy. The system and methods increase the SCS therapy by increasing at least one of an amplitude, a duration, and number of the SCS pulses associated with the SCS therapy. The system and methods also include iteratively repeat the delivering, determining and increasing operations until the ECAP amplitude exhibits a downward trend divergence. The system and methods define a stimulation threshold based on the ECAP amplitude at the trend divergence.

System and method for determining a stimulation threshold for closed loop spinal cord stimulation

A system and method for controlling non-paresthesia stimulation of neural tissue of a patient. The method delivers a non-paresthesia stimulation waveform, senses sensory action potential (SAP) signals from the neural tissue of interest and analyzes the SAP signals to obtain SAP activity data for at least one of an SAP C-fiber component or an SAP A-delta fiber component. The method determines whether the SAP activity data satisfies a criteria of interest and adjusts at least one of the therapy parameters to change the non-paresthesia stimulation waveform when the SAP activity data does not satisfy the criteria of interest.

System and method to control a non-paresthesia stimulation based on sensory action potentials

The present disclosure provides a spinal cord stimulation (SCS) system. The system includes at least one SCS lead including a lead body, at least one distal electrode located at a distal end of the lead body, the at least one distal electrode configured to apply electrical stimulation to a stimulation target of a patient, and a pain reduction assembly coupled to the lead body and configured to reduce post-operation pain at an incision site associated with implantation of the at least one SCS lead. The system further includes a pulse generator coupled to the at least one SCS lead and configured to control electrical stimulation delivered to the patient via the at least one SCS lead.

Systems and methods for reducing pain during spinal cord stimulation trial

System and methods are provided for determining a stimulation threshold for closed loop spinal cord stimulation (SCS). The system and methods provide a lead coupled to an implantable pulse generator (IPG). The system and methods deliver SCS pulses from the IPG to the lead electrodes in accordance with an SCS therapy, and determine an evoked compound action potential (ECAP) amplitude based on an ECAP waveform resulting from the SCS therapy. The system and methods increase the SCS therapy by increasing at least one of an amplitude, a duration, and number of the SCS pulses associated with the SCS therapy. The system and methods also include iteratively repeat the delivering, determining and increasing operations until the ECAP amplitude exhibits a downward trend divergence. The system and methods define a stimulation threshold based on the ECAP amplitude at the trend divergence.

A system and method for controlling non-paresthesia stimulation of neural tissue of a patient. The method delivers a non-paresthesia stimulation waveform, senses sensory action potential (SAP) signals from the neural tissue of interest, and analyzes the SAP signals to obtain SAP activity data for at least one of an SAP C-fiber component or an SAP A-delta fiber component. The method determines whether the SAP activity data satisfies a criteria of interest and adjusts at least one of the therapy parameters to change the non-paresthesia stimulation waveform when the SAP activity data does not satisfy the criteria of interest.

The present disclosure may take the form of a method of optimizing CRT wherein candidate pacing settings are administered at a candidate lead implantation site. Such a method may comprise: determining a navigation sensor path at a measurement site for each candidate pacing setting at the candidate lead implantation site; and identifying which navigation sensor path corresponds to a most efficient cardiac tissue displacement.

Systems for, and methods of, guidance based intraoperative cardiac resynchronization therapy optimization

Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's arterial blood pressure while a patient's heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient's heart is obtained using a sensor or electrodes that are implanted remote from the patient's heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.

Arterial blood pressure monitoring devices, systems and methods for use while pacing

A system and method for controlling non-paresthesia stimulation of nervous tissue of a patient. The method delivers a non-paresthesia stimulation waveform, senses sensory action potential (SAP) signals from the nervous tissue of interest, and analyzes the SAP signals to obtain SAP activity data for at least one of an SAP C-fiber component or an SAP A-delta fiber component. The method determines whether the SAP activity data satisfies a criteria of interest and adjusts at least one of the therapy parameters to change the non-paresthesia stimulation waveform when the SAP activity data does not satisfy the criteria of interest.

A system and method for delivering coupled burst and tonic stimulation of nervous tissue is provided. The system and method includes providing a lead with at least one stimulation electrode configured to be implanted at a target position proximate to nervous tissue of interest. The system and method further includes coupling the lead to an implantable pulse generator (IPG). The method delivers a first current pulse configured as a tonic stimulation waveform to the at least one electrode. The tonic stimulation waveform is configured to excite A-beta fibers of the nervous tissue. After a tonic-burst delay, the IPG delivers second current pulses configured as a burst stimulation waveform to at least one electrode. The burst stimulation waveform is configured to excite C-fibers of the nervous tissue.

System and method for coupling burst and tonic stimulation

A system and method for treating an arrhythmia in a heart are provided. The system includes an electronic control unit configured to monitor movement of one or more position sensor over a period of time. The position sensors may, for example, comprise electrodes or coils configured to generate induced voltages and currents in the presence of electromagnetic fields. The positions sensors are in contact with portions of heart tissue and changes in position are representative of motion of that tissue. The electronic control unit is further configured to generate an indicator, responsive to the movements of the sensors over the period of time, of a characteristic of the heart affected by delivery of ablation energy to heart tissue. In this manner, the effectiveness and safety of cardiac tissue ablation for treatment of the arrhythmia can be assessed and a post-ablation therapy regimen determined.

System and method for treating arrhythmias in the heart using information obtained from heart wall motion

The present disclosure provides systems and methods for providing both neurostimulation and defibrillation therapy. The system includes an implantable pulse generator (IPG), at least one neurostimulation electrode electrically coupled to the IPG and configured to apply neurostimulation pulses to a subject, and at least one defibrillation electrode electrically coupled to the IPG and configured to apply defibrillation pulses to the subject.

Systems and methods for combined neurostimulation and defibrillation therapy

A system and method are provided for controlling stimulation of nervous tissue of a patient. The method comprises delivering a stimulation waveform to at least one electrode located proximate to nervous tissue of interest, the stimulation waveform including a series of pulses configured to excite at least one of A-beta (A&#x3b2;) fibers, A-delta (A&#x3b4;) fibers or C-fibers of the nervous tissue of interest, the stimulation waveform defined by therapy parameters. The method also provides sensing an evoked compound action potential (ECAP) signal from the nervous tissue of interest. The method also analyzes a frequency content of the ECAP signal to obtain ECAP frequency data indicative of activity by at least one type of nerve fibers from a group comprising A&#x3b2;, A&#x3b4; and C fibers. The method also determines the type of nerve fibers that were activated by the stimulation waveform based on the ECAP frequency data.

System and method to control dorsal root stimulation parameters based on frequency decomposition

A method and system are provided for characterizing chamber specific function. The method and system comprise collecting cardiac signals associated with asynchronous timing between first and second chambers of the heart; collecting dynamic impedance (DI) data along a chamber-specific function (CSF) vector to form a DI data set, the DI data set collected during a collection window that is temporally aligned based on a timing feature of interest (FOI); repeating the collection operations over multiple cardiac cycles (CC) to obtain an ensemble of DI data sets; and combining the ensemble of DI data sets to form a composite DI data set that is coupled to a chamber functional mechanic of interest (FMOI) associated with the first chamber and decoupled from functional mechanics associated with the second chamber; and analyzing the composite DI data set to obtain a CSF indicator associated with the chamber FMOI of the first chamber.

Method and system for characterizing chamber specific function

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Lancaster, CA, United States of America

Wenbo Hou