China Pharmaceutical University

Jiangsu Simcere Pharmaceutical R&d Co., Ltd

Shandong Xiansheng Maidejin Biological Pharmaceutical Co., Ltd.

Wenbing Yao

Hong Tian

Xiangdong Gao

Yi Xu

Xiangyang Xu

Hairui Li

Yue Dong

Yu He

A helper epitope peptide is obtained by means of replacing one or two amino acid residues in the helper T cell epitope PADRE with 4-nitrophenylalanine. The helper epitope peptide is effective for enhancing the immunogenicity of an antigen or antigenic epitope or for preparing or constructing a vaccine, and a fusion antigen formed by connecting the helper epitope peptide to an antigen or an antigenic epitope.

Helper epitope peptide and application thereof

Provided is a kind of modified recombinant human endostatin that has the structure of CHO&#x2014;(CHCHO)&#x2014;CHCHCH&#x2014;NH-Endostar, wherein the average molecular weight of CHO&#x2014;(CHCHO)&#x2014;CHCHCH&#x2014; is 20-40 kD. The modified recombinant human endostatin enhances the stability in vivo, improves blood drug concentration, prolongs half-life, markedly increases the activity of inhibiting the endothelial cells proliferation, thus reduces drug dosage and decreases administration frequency. Its application for preparing anti-tumor pharmaceutical compositions is also provided.

Modified recombinant human endostatin and uses thereof

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Jiangsu, China

Wenbing Yao