Xenon Pharmaceuticals Inc.

Wenbao Li

Shaoyi Sun

Serguei Sviridov

Rajender Kamboj

Shifeng Liu

Vishnumurthy Kodumuru

Melwyn A Abreo

Michael D Winther

Heinz W Gschwend

Chi Tu

Zaihui Zhang

Mark W Holladay

Nagasree Chakka

Vandna Raina

Daniel F Harvey

Mikhail Kondratenko

Sultan Chowdhury

Mikhail A Chafeev

Jian-Min Fu

Duanjie Hou

Boris Klebansky

Mehran Seid Bagherzadeh

Sengen Sun

Cindy J Hudson

Robert Fraser

Kashinath Sadalapure

Mikhail A Kondratenko

Jian-min Fu

Mikhail Chafev

Kashinath Sadalupure

Sun Shaoyi

Michael Winther

Heinz Gschwend

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): 

Pyridyl derivatives and their use as therapeutic agents

Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents

This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain. 

Combination therapy

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R, R, R, R, R, R, R, Ra, R, Ra, R, R, Rand Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed. 

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Pyridazine derivatives and their use as therapeutic agents

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is &#x2014;O&#x2014;, &#x2014;N(R1)&#x2014;, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)&#x2014;, C(O)O&#x2014;, S(O)2&#x2014;, S(O)2N(R1)&#x2014; or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7, R8, R8, R9, R9, R10 and R10are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed. 

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R, R, R, R, R, R, R, R, R, R, R, R, Rand Ra are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed. 

Piperazine derivatives and their use as therapeutic agents

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San Diego, CA, United States of America

Wenbao Li