The United States of America, as Represented by the Secretary, Department of Health and Human Services

Dana-Farber-Cancer Institute Inc.

Wen Yuan

Gary J Nabel

Peter D Kwong

John R Mascola

Joseph G Sodroski

Tongqing Zhou

Richard Wyatt

Ling Xu

Barna Dey

Shi-Hua Xiang

Chih-Chin Huang

Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.

Conformationally stabilized HIV envelope immunogens

Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.

Conformationally stabilized HIV envelope immunogens and triggering HIV-I envelope to reveal cryptic V3-loop epitopes

Growing community of inventors

Brighton, MA, United States of America

Wen Yuan