Regeneron Pharmaceuticals, Inc.

Wen-Yi Lee

Gang Chen

Robert Babb

Andrew J Murphy

George D Yancopoulos

William C Olson

Neil E Stahl

Christos Kyratsous

Tammy T Huang

Alina Baum

Johanna Hansen

Marine Malbec

Cindy Gerson

Ergang Shi

David Suh

Glen Farr

Disclosed are methods for obtaining cells that express antibodies that bind transmembrane proteins, methods for generating antibodies from such cells, antibodies to transmembrane proteins and fragments thereof, and nucleic acids encoding the antibodies. More particularly, the disclosure relates to methods for obtaining antibody-producing cells that express an antibody that binds to a transmembrane protein based on the use of lipid bilayer-membrane scaffold protein complexes to present transmembrane protein antigens to cells.

Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same

The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments

Anti-SARS-CoV-2-Spike glycoprotein antibodies and antigen-binding fragments

Growing community of inventors

New Hyde Park, NY, United States of America

Wen-Yi Lee