Scinopharm Taiwan, Ltd.

Wen-Wei Lin

Tsung-Cheng Hu

Kuan-Hsun Wang

Wei-Shuo Lo

Yuan-Chang Huang

Ying-Tzu Lin

Wan-Yin Cheng

YuanChang Huang

Ming-Chih Wu

Yung-Hung Chang

In certain aspects, the invention provides a novel crystalline form of olaparib (4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl]methyl(2H)phthalazin-1-one). In related aspects, the invention provides a processe for preparing the novel crystalline form of olaparib. The process includes forming a solution comprising crude olaparib and an organic solvent; adding the solution to an anti-solvent to form a slurry comprising a precipitate; isolating the precipitate; and drying the precipitate to obtain a crystalline form III of olaparib.

Crystalline form of olaparib and a process for preparing the same

Crystalline form S1 of lifitegrast characterized by a powder X-ray diffraction pattern with peaks at about 10.7&#xb1;0.2, 16.2&#xb1;0.2, 19.9&#xb1;0.2, 22.1&#xb1;0.2, 24.7&#xb1;0.2, and 25.9&#xb1;0.2 degrees two-theta, crystalline form S2 of lifitegrast characterized by a powder X-ray diffraction pattern with peaks at about 16.4&#xb1;0.2, 24.9&#xb1;0.2, and 26.2&#xb1;0.2 degrees two-theta, and processes of making thereof are provided.

Crystal forms of lifitegrast

In certain aspects, the invention provides crystalline forms of olaparib (4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl]methyl(2H)phthalazin-1-one). In related aspects, the invention provides processes for preparing the crystalline forms of olaparib. The processes include: forming a solution comprising crude olaparib and an organic solvent; adding an anti-solvent to the solution to form a slurry comprising a precipitate; isolating the precipitate; and drying the precipitate to obtain a crystalline form I of olaparib or a crystalline form II of olaparib.

Crystalline forms of olaparib and manufacturing processes therefor

Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for the preparation of Forms 1 and 2 are also provided.

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Tainan, Taiwan

Wen-Wei Lin