Bristol-myers Squibb Compnay

Wen-sen Li

Ramesh N Patel

Ronald L Hanson

John J Venit

Paul Alan Jass

Keith Ramig

Laszlo J Szarka

Steven L Goldberg

Mary Jo Donovan

Philip Michael Sher

Mark E Salvati

Toomas Mitt

James H Simpson

Animesh Goswami

David B Brzozowski

Shankar Swaminathan

Ambarish K Singh

Linda Nga Hoong Chu

Michael J Totleben

Weixuan He

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof

Substituted alkylketo compounds and process

Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

Stereoselective reductive amination of ketones

A method is provided for preparing intermediates for 7-oxabicycloheptane carboxylic acid intermediates of the structures ##STR1## wherein R is alkyl, aryl, arylalkyl or cycloalkyl; R.sup.1 is alkyl, arylalkyl or cycloalkyl; R.sup.2 is aryl or arylalkyl; and of the structure ##STR2## where R and R.sup.1 are as defined above, which may be used in making the final anti-thrombotic--anti-vasospastic compounds.

7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates

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Holmdel, NJ, United States of America

Wen-sen Li