Bristol-myers Squibb Compnay

E. R. Squibb Sons, Inc.

Wen-Sen Li

John K Thottathil

David J Kucera

Ivan D Trifunovich

David R Kronenthal

Yadagiri Pendri

John F Kadow

Murray A Kaplan

Dolatrai M Vyas

Mark D Wittman

John J Wright

Henry S Wong

Robert K Perrone

Jerzy Golik

Michael Murphy

Novel &#x3b2;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &#x3b2;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

&#x3b2;-Lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes

The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Phosphonooxymethyl ethers of taxane derivatives

Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

&bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes

Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxes such as tall and tall derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxes, and to novel sidechain-bearing taxes.

Reduction and resolution methods for the preparation of compounds useful as intermediates in the preparation of taxanes, and particularly for preparation of desired stereoisomers for use in the formation of the C-13 sidechain of pharmaceutically useful taxanes such as paclitaxel.

Reduction and resolution methods for the preparation of compounds useful

A novel, overall process for the preparation of a compound of the formula I: ##STR1## where R.sup.1 and R.sup.2 are each independently hydrogen, an alkyl group, a cycloalkyl group, an aryl group or, taken together with the carbon atom to which they are attached, form a cycloalkyl group; and

Process for the preparation of 1,3-dioxane derivatives useful in the

A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R.sub.3, R.sub.4 and Y are as defined herein, which intermediates are useful in a process for the preparation of pharmaceutically useful benzazepine derivatives.

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Lincroft, NJ, United States of America

Wen-Sen Li