The United States of America, As Represented by the Secretary, Department of Health and Human Services

University System of Maryland

Wen Qing Li

Scott Durum

Julie Hixon

Scott Walsh

Lila Kashi

Antibodies and antigen binding fragments that specifically bind to IL-7Rα are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7Rα using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7Rα, such as acute lymphoblastic leukemia.

Il-7R-alpha specific antibodies for treating acute lymphoblastic leukemia

Antibodies and antigen binding fragments that specifically bind to IL-7R&#x3b1; are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R&#x3b1; using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R&#x3b1;, such as acute lymphoblastic leukemia.

Growing community of inventors

Frederick, MD, United States of America

Wen Qing Li