National Taiwan University

National Cheng-Kung University

Yung Shin Pharmaceutical Ind. Co., Ltd.

Carlsbad Technology, Inc.

Ko Da Pharmaceuticals Co., Ltd.

Dcb-usa LLC

Wen-Mei Fu

Woei-Jer Chuang

Sheng-Chu Kuo

Che-Ming Teng

Chih-Hsin Tang

Yen-Lun Huang

Fang-Yu Lee

Mannching Sherry Ku

Tur-Fu Huang

Wenya Huang

Rong-Sen Yang

Chiu-Yueh Chen

Chao Hsiang Chen

Mei-Yin Chien

Jin-Ming Chang

Keng-Chen Liang

Wei-Lin Chien

Fang-Yuan Lee

Houng-Chin Liou

Dah-Yuu Lu

The invention generally relates to compositions and methods of treatment and/or prevention of angiogenesis-related eye diseases using low doses of rhodostomin variants, and in particular, low doses of a fusion protein comprising a rhodostomin variant, wherein the rhodostomin variant is conjugated with a variant of Human Serum Albumin (HSA) where the cysteine residue at position 34 of the HSA amino acid sequence has been replaced with serine.

Compositions and methods for the treatment of angiogenesis-related eye diseases

The invention provides disintegrin variants, and more specifically to disintegrin variants which are selective &#x3b1;v&#x3b2;3 integrin antagonists for treatment and prevention of &#x3b1;v&#x3b2;3 integrin-associated diseases. The present invention also relates to pegylated proteins, including proteins comprising a disintegrin variant having an RGD motif variantARLDDL. The invention also relates to the use of the polypeptides of the invention for the treatment and prevention of &#x3b1;v&#x3b2;3 integrin-associated diseases.

Methods of treating &#x3b1;v&#x3b2;3 integrin-associated diseases by administering polypeptides selective for &#x3b1;v&#x3b2;3 integrin

Disintegrin variants and pharmaceutical uses thereof are disclosed. The disintegrin variant includes an isolated polypeptide that has integrin &#x3b1;v&#x3b2;3 receptor-antagonist activity and substantially reduced integrin &#x3b1;llb&#x3b2;3 and/or &#x3b1;5&#x3b2;1 receptor-blocking activity as compared to a wild-type disintegrin. The variant is encoded by a modified disintegrin nucleotide sequence that encodes a modified amino acid sequence, resulting in a polypeptide having substantially reduced affinity to integrin &#x3b1;llb&#x3b2;3 and/or &#x3b1;5&#x3b2;1 as compared to a wild-type disintegrin. The variant is useful for treatment and/or prevention of &#x3b1;v&#x3b2;3 integrin-associated diseases in a mammal, which include osteoporosis, bone tumor or cancer growth, angiogenesis-related tumor growth and metastasis, tumor metastasis in bone, malignancy-induced hypercalcemia, angiogenesis-related eye diseases, Paget's disease, rheumatic arthritis, and osteoarthritis. The angiogenesis-related eye diseases include age-related macular degeneration, diabetic retinopathy, corneal neovascularizing diseases, ischaemia-induced neovascularizing retinopathy, high myopia, and retinopathy of prematurity.

Disintegrin variants and their use in treating osteoporosis-induced bone loss and angiogenesis-related diseases

A pharmaceutical composition for preventing and/or treating bone loss is disclosed. The pharmaceutical composition includes an effective amount of a licorice, black bean, Cnidi Fructus, and buckhorn.

Pharmaceutical composition for prevention and/or treatment of bone loss

This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula: A is H, R, or each of Ar, Ar, and Ar, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R, R, R, R, R, and R, independently, is H, halogen, R, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH, C(O)NHR, C(O)NRR', ROH, ROR&#x2032;, RSH, RSR&#x2032;, NHR, NRR&#x2032;, RNHR&#x2032;, or RNR&#x2032;R&#x2033;; or Rand Rtogether, Rand Rtogether, or Rand Rtogether are ORO; wherein each of R, R&#x2032;, and R&#x2033;, independently is C&#x2dc;Calkyl; and n is 1, 2, or 3.

Method of increasing bone density or treating osteoporosis

A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I):  

Enhancement of learning and memory and treatment of amnesia

Growing community of inventors

Taipei, Taiwan

Wen-Mei Fu