Js Innopharm (shanghai) Ltd.

Changzhou Jiekai Pharmatech Co., Ltd.

Siemens Aktiengesellschaft

Shanghai Micro Electronics Equipment (group) Co., Ltd.

Shanghai Micro Electronics Equipment Co., Ltd.

Js Innomed Holdings Ltd.

Js Innopharm Ltd.

Wen Kang Xu

Jintao Zhang

Shanzhong Jian

Fan Wang

Ao Qiong Li

Qun Li

Pengli Zhang

Shun Jie Fan

Hailiang Lu

Junwei Jia

Hongji Zhou

The present disclosure provides a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds. They are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof

An automatic optical inspection (AOI) device and method are disclosed. The device is adapted to inspect an object under inspection (OUI) () carried on a workpiece stage () and includes: a plurality of detectors () for capturing images of the OUI (); a plurality of light sources () for illuminating the OUI () in different illumination modes; and a synchronization controller () signal-coupled to both the plurality of detectors () and the plurality of light sources (). The synchronization controller () is configured to directly or indirectly control the plurality of detectors () and the plurality of light sources () based on the position of the OUI () so that each of them is individually activated and deactivated according to a timing profile, that each of the detectors () is able to capture images of the OUI () in an illumination mode provided by a corresponding one of the light sources (), and that when any one of the light sources () is illuminating the OUI (), only the one of the detectors () corresponding to this light source () is activated. Through the timing control over the multiple light sources () and detectors () by the synchronization controller (), inspection with multiple measurement configurations can be accomplished within a single scan, resulting in a significant improvement in inspection efficiency.

Automatic optical inspection device and method

Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleamine 2, 3-dioxygenase 1 (IDO1), potentially useful in the treatment of diseases treatable, such as cancers. 

Heterocyclic compounds, compositions comprising heterocyclic compound, and methods of use thereof

An interconnection device, a communication method, and a system including a robot are disclosed. In an embodiment, the interconnection device includes a first OPC UA interface, configured to establish connection between the interconnection device and an OPC UA device; and an ROS interface, in communication with the first OPC UA interface. The ROS interface includes: at least one ROS node module, configured to perform communication between the OPC UA device and an ROS device; an ROS client library module, configured to provide a function library to be called when the ROS node module performs the communication; and an ROS core module, configured to manage the ROS node module in the ROS interface unit and a node module in the ROS device. Communication between the OPC UA device and the ROS device is achieved via the interconnection device and the communication method.

Interconnection device, communication method, and system including robot

(I) Disclosed herein are compounds of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds, which are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers, as well as pharmaceutical compositions, comprising a compound of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 

Disclosed herein is a compound of formula (I) and/or a pharmaceutically acceptable salt thereof that can serve as Erk inhibitors. They are potentially useful in the treatment of diseases treatable by inhibition of Erk, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of formula I and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. 

Pyrazolo fused heterocyclic compounds as ERK inhibitors

Disclosed herein is a compound of formula I and/or a pharmaceutically acceptable salt thereof that can serve as Erk inhibitors: They are potentially useful in the treatment of diseases treatable by inhibition of Erk, such as cancers. Also disclosed herein is a pharmaceutical composition comprising a compound of formula I and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

Heterocyclic compounds as ERK inhibitors

An off-axis alignment system includes, sequentially along a transmission path of a light beam, an illumination module (), an interference module () and a detection module (). The interference module () includes: a polarization beam splitter () having four side faces, the illumination module () and the detection modules () both located on a first side of the polarization beam splitter (); a first quarter-wave plate () and a first reflector (), sequentially disposed on a second side opposite to the first side; and a second quarter-wave plate () and a cube-corner prism (), sequentially disposed on a third side of the polarization beam splitter (); and a third quarter-wave plate (), a second reflector () and a lens (), sequentially disposed on a fourth side of the polarization beam splitter (). The second reflector () is located on a rear focal plane of the lens (). A center of a bottom of the cube-corner prism () is situated on an optical axis of the lens (). An off-axis alignment method is also disclosed.

Growing community of inventors

Shanghai, China

Wen Kang Xu