W. L. Gore & Associates, Inc.

Eli Lilly and Company

Xiamen University

Gore Enterprise Holdings, Inc.

Sanford-burnham Medical Research Institute

The Burnham Institute

Sanford Burnham Prebys Medical Discovery Institute

Wen K Liu

William B Johnson

Anthony A Estrada

Paul D Drumheller

Snahel Patel

Kevin X Chen

Xin Kang Chen

Jack J Hegenbarth

Rachel Radspinner

Ping Xu

Adam Robert Mezo

Paul Gibbons

Xiao-kun Zhang

Francisco Alcides Valenzuela

Hu Zhou

Ying Su

Pei-Qiang Huang

Alexander Agapov

William Shamrock

Thomas Berta

Xihua Cao

Simon J C Cleghorn

Joshua M Bartels

Daniel Shore

Alan Olivero

Xiao-Kun Zhang

Michael Siu

Changyou Ma

Malcolm Huestis

Liting Dong

Terry Kellar

This disclosure relates to electrolyzer composite membranes, and in particular, to a composite membrane having at least two reinforcing layers comprising a microporous polymer structure and a surprisingly high resistance to piercing. The electrolyzer composite membranes have a recombination catalyst configured to be disposed closer to an anode than to a cathode in a membrane-electrode assembly (MEA). The disclosure also relates to membrane-electrode assemblies and electrolyzers comprising the membranes, and to method of manufacture of the membranes.

Electrochemical membrane

The presently described compounds relate to the treatment of diabetes and/or hyperglycemia. More particularly, the described compounds relate to acylated insulin compounds that lower blood glucose, pharmaceutical compositions containing such compounds, therapeutic uses of such compounds, and an intermediate compound used to make the acylated insulin compounds.

Acylated insulin compound

Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenviroment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.

Methods and compositions related to retinoid receptor-selective pathway

Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.

Methods and compositions related to a retinoid receptor-selective pathway

A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable. Methods for making the functional TFE copolymer are also described. The expanded functional TFE copolymer material may be post-reacted after expansion.

Expandable functional TFE copolymer fine powder, expanded products and reacted products therefrom

Expandable functional TFE copolymer fine powder, the expanded functional products obtained therefrom and reaction of the expanded products

A solid polymer electrolyte membrane having a first surface and a second surface opposite the first surface, where the solid polymer electrolyte membrane has a failure force greater than about 115 grams and comprises a composite membrane consisting essentially of (a) at least one expanded PTFE membrane having a porous microstructure of polymeric fibrils, and (b) at least one ion exchange material impregnated throughout the porous microstructure of the expanded PTFE membrane so as to render an interior volume of the expanded PTFE membrane substantially occlusive; (c) at least one substantially occlusive, electronically insulating first composite layer interposed between the expanded PTFE membrane and the first surface, the first composite layer comprising a plurality of first carbon particles supporting a catalyst comprising platinum and an ion exchange material.

Solid polymer electrolyte and process for making same

This invention relates to methods for identifying agents useful for treatment of diseases and pathological conditions affected by Retinoid X Receptor apoptosis. The invention also relates to methods for treating diseases and pathological conditions affected by RXR apoptosis. The invention includes compositions that are useful in the study and treatment of diseases and pathological conditions affected by RXR apoptosis.

Cytoplasmic activity of retinoid X receptor and its regulation by ligands and dimerization

The invention is a method of reducing catalyst dissolution in the cathode of a membrane electrode assembly fuel cell, the method comprising the steps of: (a) preparing a membrane electrode assembly comprising an anode, a cathode and a polymer electrolyte membrane interposed between the anode and the cathode; (b) assembling a fuel cell using the membrane electrode assembly; (c) applying a fluid comprising an oxidant to the cathode of the_membrane electrode assembly; (d) applying a fluid comprising a fuel to the anode of the membrane electrode assembly; and (e) supplying a sufficient quantity of reducing agent to the cathode to maintain the average open-circuit voltage of the cathode at less than about 0.98 V.

Method for reducing degradation in a fuel cell

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Newark, DE, United States of America

Wen K Liu