Bristol-myers Squibb Compnay

Universitéde Montreal

Wen Jiang

Xiaojun Zhang

Heather J Finlay

Wei Meng

Eldon Scott Priestley

George O Tora

Jeremy M Richter

Oz Scott Halpern

Samuel Kaye Reznik

R Michael Lawrence

Edward H Ruediger

Wu Yang

James A Johnson

Zulan Pi

Robert Paul Brigance

Rejean Ruel

Michael C Myers

Sasmita Tripathy

Monique Phillips

Donna M Bilder

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Biarylmethyl heterocycles

Disclosed are compounds of Formula (I) to (VIII): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein Ris a tricyclic heteroaryl group substituted with Rand zero to 2 R; and R, R, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or &#x3b2;-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as APJ agonists

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments. 

6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1H)-one as APJ agonists

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Furlong, PA, United States of America

Wen Jiang