University of Alberta

Wen Fu

Jack Jhamandas

Michael Houghton

D Lorne Tyrrell

James Nieman

Mostofa Hena

Appan Srinivas Kandadai

Alexandr Belovodskiy

Ryoichi Kimura

Kamlesh Kumar Sahu

Rania Soudy

Bing Bai

Kamaljit Kaur

David MacTavish

Aarti Patel

The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.

Compounds for the treatment of Alzheimer's disease

Amylin receptor antagonists capable of binding to the amylin receptor and inhibiting activity of amylin or amyloid-beta protein are provided. The amylin receptor antagonists can be administered in the form of pharmaceutical compositions or the like. Methods for preparing and using the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease are also provided.

Brain penetrant amylin receptor based peptides for Alzheimer's disease

Growing community of inventors

Edmonton, Canada

Wen Fu