Other

Taipei Medical University

Taiyen Biotech Co., Ltd.

Taipei Biotechnology Ltd., Inc.

Wen-Fu Lai

Chun-Wei Chen

Shih-Ching Chen

Li-Chern Pan

Yu-Hui Tsai

Jung-Chou Oung

Li-Hsuan Chiu

Chin-Chean Wong

Ja-Reng Tang

Chien-Tsu Chen

Pau-Yee Lim

The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes.

Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro

This invention relates to a bone implant that includes a bioinert substrate covered with a ceramic layer containing a plurality of indentations. The total surface area of the indentations is 30-70% of the total surface area of the ceramic layer. This invention also relates to a method of preparing such a bone implant. The method includes: (1) affixing a ceramic layer on the surface of a bioinert substrate; (2) forming a plurality of indentations in the ceramic layer, wherein the total surface area of the indentations is 30-70% of the total surface area of the ceramic layer; and (3) immobilizing a biopolymer onto the ceramic layer via covalent bonding.

Bone implants

A method of fabricating a cartilage implant including embedding and growing chondrocytes or mesenchymal stem cells in a three-dimensional substrate. The substrate contains randomly rewound &#x3b1;-helical monomers of type I collagen.

Fabrication of a cartilage implant

The present invention relates to a process of preparation of a new reconstituted collagen template and further to the reconstituted collagen template being able to cure articular destruction in a mammal.

Reconstituted collagen template and the process to prepare the same

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Taipei, Taiwan

Wen-Fu Lai