Tsinghua University

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Institute of Nuclear Energy Research, Atomic Energy Council

Wen-Chin Su

Wuu-Jyh Lin

Jenn-Tzong Chen

Chung-Shan Yu

Ho-Lien Huang

Ching-Shiuann Yang

Ting-Shien Duh

Shiou-Shiow Farn

Li-Yuan Huang

Jia-Rong Chen

Chun-Nan Yeh

Wei-Yuan Lee

Kang-Wei Chang

Ying-Cheng Huang

Yen-Hung Tu

Kun-Ju Lin

Shu-Fan Tien

The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.

Method for F-18 FLT synthesis

The present invention provides a method of preparing [I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/&#x3bc;mol and radiochemical purity of 95%. The present invention further provides a method of applying [I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.

[object Object]

A tumor radiation probe of iodine-123 marker thymidine (FLT) analogue [I]-IaraU is disclosed. Commercial available uridine is used as the raw material for the synthesis of the precursor. A radioactive iodine-123 is marked on an alkaline group of uridine to obtain [I]-IaraU, which is distinguishable from [F]-FLT markingF on a glycosyl group to obtain a novel tumor radiation probe. The marking procedures include mixing the marker precursor with Na [I] solution, acetic acid and hydrogen peroxide solution, and the solution of chloroform and sodium hydroxide. The sonication time increases from 1 minute to 10 minutes, so that [I]-IaraU has radiologically chemical purity of higher than 98% and radiological specific activity of not less than 0.196 GBq/umole, and the yield can increase from 8% to 40%. Its radioactive specific activity, yield and purity reach to the degree for the use in biological experiments, while reducing production cost.

Growing community of inventors

Taoyuan County, Taiwan

Wen-Chin Su