E. R. Squibb Sons, Inc.

Wen-Chih Liu

Richard B Sykes

Edward Meyers

Terrence W Doyle

William L Parker

Jerry S Wells

Pushpa Singh

Veeraswamy Manne

William E Brown

Gordon W Robinson

Dorothy S Slusarchyk

Karen Bush

Gail L Astle

William Lawrence Parker

Richard Brook Sykes

10'-Desmethoxystreptonigrin, obtainable by cultivation of a strain of Streptomyces albus, A.T.C.C. No. 55161, and salts, esters and amides thereof. The novel compounds have antitumor and antibiotic activity.

10'desmethoxystreptonigrin production by Streptomyces albus

Two related, novel antibiotic substances, peptifluorin and neopeptifluorin, are prepared by cultivation of strains of Pseudomonas fluorescens, A. T. C. C. No. 53,958 and A. T. C. C. No. 55,129, respectively.

Peptifluorin and neopeptifluorin

10'-Desmethoxystreptonigrin

Aerocavin, a novel antibiotic substance having the structure ##STR1## and aerocyanidin, a novel antibiotic substance having the structure ##STR2## can be prepared by cultivation of the microorganism Aerocavin caviae SC 14,030 A.T.C.C. No. 53434.

Aerocyanidin-antibiotic

Aerocavin antibiotics

Cultivation of a strain of the microorganism Pseudomonas cepacia which has been deposited in the American Type Culture Collection as A.T.C.C. No. 39277, yields novel antibiotic substances xylocandin A and xylocandin B having activity against yeasts and fungi.

Antibiotics xylocandin A and xylocandin B

3,6-Dihydroxyphenazine-1-carboxylic acid, a hypotensive agent, and its production by culturing aerobically Streptomyces species A.T.C.C. No. 39460 are disclosed herein.

Phenazine ACE inhibitor produced from streptomyces species

Cultivation of a strain of the microorganism Nocardia sp. 11,340, which has been deposited in the American Type Culture Collection as A.T.C.C. No. 31531, yields a novel antibiotic substance EM 4940, having activity against a range of gram-positive and gram-negative bacteria, yeasts, fungi, acholeplasma, and the protozoan Trichomonas vaginalis.

Process for preparing antibiotic EM 4940

Cultivation of a strain of the microorganism Nocardia sp. 11,340, which has been deposited in the American Type Culture Collection as A.T.C.C. No. 31531, yields a novel antibiotic substance EM 4940, having activity against a range of gram-positive and gram-negative bacteria, yeasts, fungi, acholeplasma, and the protozoan Trichomanas vaginalis.

3,4-Dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-4-me

A method is provided for recovering a polyether antibiotic, such as lonomycin, monensin or ionomycin from a fermentation broth, wherein the polyether is first extracted with a water-immiscible solvent, such as ethyl acetate, and the resulting extracts concentrated, dissolved in aqueous methanol and then extracted into hexane, benzene or mixtures thereof. The polyether is thereby recovered in crystalline form directly from the latter extract.

Growing community of inventors

Princeton Junction, NJ, United States of America

Wen-Chih Liu