Shenzhen Neptunus Pharmaceutical Co., Ltd.

Shenzhen Neptunus Pharmaceutical Holdings Co., Ltd.

Weizhen Zeng

Hui Kang

Lin Yu

Hanlin Feng

Jinhua Zhao

Yong Li

Yuan Gao

Jing Li

Hong Chen

Zhiguo Wang

Zi Li

Dan Zhu

Jing Cui

Cunfang Wang

Lijuan Zhang

Chuangui Huang

Yu Man

Mingyi Wu

Guanghui Yao

Milai Yin

Disclosed is a depolymerized glycosaminoglycan from(dTHG), weight average molecular weight of which is about 8000&#x2dc;20000 Da, and monosaccharide components of which are acetylgalactosamine (GalNAc), glucuronic acid (GlcUA), fucose (Fuc) or their sulfates (expressed as &#x2014;OSO), in which molar ratio of GalNAc:GlcUA:Fuc:&#x2014;OSOis about 1:(1&#xb1;0.3):(1&#xb1;0.3):(3.5&#xb1;0.5). Said dTHG is a potent endogenous inhibitor of factor X, which has good anticoagulant and antithrombotic activity, and can be used for the prevention and/or treatment of thrombotic diseases. Also provided is a method for preparing said dTHG, which comprises steps of 1) extracting and obtaining fucosylated glycosaminoglycan (THG) from the body wall of; 2) depolymerizing THG to obtain dTHG by method of peroxide depolymerization or method of peroxide depolymerization catalyzed by catalyst of the fourth period transition metal ions; 3) removing impurities with lower and/or higher molecular weight in dTHG.

[object Object]

The present invention relates to a novel crystalline form of a Compound 3,4',5-trihydroxy-stilbene-3-&#x3b2;-D-glucoside (polydatin) and a method of preparation and use thereof, and to a pharmaceutical composition containing crystalline form I of 3,4&#x2032;,5-trihydroxy-stilbene-3-&#x3b2;-D-glucoside. Crystalline form I of 3,4&#x2032;,5-trihydroxy-stilbene-3-&#x3b2;-D-glucoside of the present invention has a stable crystalline morphology, a definite melting point and a good chemical stability. Such a novel form of 3,4&#x2032;,5-trihydroxy-stilbene-3-&#x3b2;-D-glucoside possesses the properties required for the preparation of solid formulations and is easily tabletable and readily formable when formulated, which allows for substantial decrease in raw materials costs, more facile operations in production and easier control over quality in industrial drug production, and moreover, better convenience in storage.

Crystalline form I of 3,4'5-trihydroxy-stilbene-3-&#x3b2;-D glucoside

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Shenzhen, China

Weizhen Zeng