Fudan University

Shanghai Whittlong Pharmaceutical Institute

Shanghai Pharmco Research, Inc.

Comprehensive Drug Enterprises Ltd.

Weiyue Lu

Chang Liu

Xin Gao

Gang Wei

Kuan Jiang

Cao Xie

Lingyu Tai

Hao Wang

Min Liu

Jun Pan

Wenjian Zhang

Huimin Hou

Xuefeng Hu

Jiani Mao

Zhilan Chai

Danni Ran

Johnson Yiu-Nam Lau

Benjamin Tak Kwong Lee

Shun Chiu Dennis Lam

The present disclosure belongs to the field of pharmaceutical preparations and relates to the design of a series of lipophilic derivatives by using wild-type penetrating peptide penetratin. These penetratin derivatives have a strong ability to penetrate the ocular tissues and do not cause ocular tissue toxicity. As ocular absorption enhancers, non-invasive routes could be used to achieve intraocular drug delivery and increase the ocular bioavailability of drugs. These penetratin derivatives and the ophthalmic drug delivery system constructed by them are used for eye drop administration, which could replace the intraocular injection with poor patients compliance, which greatly enhances the convenience and safety of the treatment of intraocular and fundus diseases.

Polypeptide-based ocular absorption enhancer and application thereof

Provided in the present invention are highly stable D-configuration polypeptides DVAP and SVAP having a high binding activity to the GRP78 protein, and also provided are an L-configuration polypeptide LVAP and a DVAP-or SVAP-modified model drug and a macromolecule carrier material, and the use thereof in the construction of a tumour image and a drug-delivery system for targeted treatment.

VAP polypeptide and use thereof in preparation of drug for targeted diagnosis and treatment of tumor

A nano drug delivery system includes a biofilm-coated drug nanocrystal. A drug in a physical form of nanocrystal is directly used as a rigid supporting skeleton, and is filled in a biofilm. The nano drug delivery system has the advantages of high drug loading capacity, good biocompatibility, long systemic circulation time and drug sustained release.

Method for preparing biofilm-coated drug nanocrystal and application thereof

Polypeptide eye absorption enhancer and use thereof

The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and uses of said composition in therapy of tumors. The folic acid-polysaccharide complexs of the present invention have general formula of: (X)&#x2014;Y, wherein X is identical or different, and is selected from folic acid, derivatives of folic acid and other substances that can enter into cell via the pathway of folic acid receptor; Y is polysaccharide; n&#x2267;1.

Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component

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Shanghai, China

Weiyue Lu