Ppd Biomarker Discovery Sciences, LLC

Weixun Wang

Christopher Hank Becker

Thomas Andrew Shaler

Scott M Norton

Curtis A Hastings

Hua Lin

Sushmita Mimi Roy

Haihong Zhou

Praveen Kumar

Markus Anderle

Relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required. The methods are particularly useful for differential phenotyping in proteomics and metabolomics research, in which molecules varying in concentration across samples are identified. These identified species may serve as biological markers for disease or response to therapy.

Mass spectrometric quantification of chemical mixture components

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Mountain View, CA, United States of America

Weixun Wang