Alza Corporation

WeiQi Lin

Michel J N Cormier

Richard L Keenan

Peter E Daddona

Joseph Creagan Trautman

James Matriano

Ahmad P Samiee

Mahmoud Ameri

Yuh-Fun Maa

A method and device are described for applying a microprotrusion member () including a plurality of microprotrusions () to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator () causes the microprotrusion member () to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (). The preferred applicator () impacts the stratum corneum with the microprotrusion member () with an impact of at least 0.05 joules per cmof the microprotrusion member () in 10 msec or less.

Apparatus and method for piercing skin with microprotrusions

The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.

Formulations for coated microprojections containing non-volatile counterions

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Palo Alto, CA, United States of America

WeiQi Lin