Other

Wayne State University

Weiping Ren

Wei Song

Xiao Wei Yu

Emily Juan-Jie Ren

A discovery of the conversion of amorphous calcium polyphosphate (ACPP) or/and other polyphosphate salts with various type of calcium phosphate to new calcium phosphate product (i.e. dicalcium phosphate dihydrate (DCPD)) in a liquid environment. The discovery includes mixing a various type of calcium phosphate with an aqueous ACPP or/and other polyphosphate salts gel, which is fast setting and possessing strong mechanical strength, and can be gradually converted to DCPD/hydroxyapatites in physiological condition. This injectable past can be applied as alternative of conventional CPC bone cement that is suitable for bone void repair due to its excellent properties in osteoconductivity and osseointegration. It can also be applied as drug delivery device in tissue engineering for its strong bonding to drug molecules.

Method of making injectable cements

The present invention describes an injectable calcium polyphosphate (CPP) gel with dense structure, which can be applied as injectable bone void filler in medical field, such as orthopedic and dental applications. Amorphous CPP powder with fine particle size (&#x3c;75 pm) can be completely dissolved in water, forming a homogeneous gelation phase separated from water phase. This homogeneous CPP gel with disentangled inorganic polyphosphate chains shows viscoelasticity and superior adhesion to natural bone, metal implant surfaces and other ceramic material surfaces. The CPP gel is biomimetic and biodegradable with strong osteoconductivity and osteoinductivity. The manufacturing procedure is easy and reproducible. The mechanical strength of CPP gel is controllable by modifications, such as sintering, incorporation of other biomaterials, etc.

Method of making water soluble injectable calcium polyphosphate gels

The present invention relates to a device for preparing three dimensional (3D) nanofibers (blended or coaxial) materials by electrospinning. An automatic nanofiber collector device is used to control the porosity, pore size, crystallinity, geometry, the layer number and thickness of formed nanofibers. The automatic nanofiber collector device includes: (1) a collector platform; (2) a non-conductive device used to fix the collector device; (3) a plurality of electro-conductive wires or needles being pierced through the collector platform with various heights, and (4) the ends of the needles (at bottom) are wired and controlled by a microcontroller, providing forward, stand and backward movements for attached needles. The desired 3D nanofiber scaffold structures can be tailored by the micro-stepping programmable motor controller by changing the pattern and velocity of needle movement, generalized or selective needles movements, as well as intermittent versus continuous movement.

Device and method for electrospinning multiple layered and three dimensional nanofibrous composite materials for tissue engineering

The present invention provides a fingerstall-cannulated guide device for accurate and efficient guide wire placement for antegrade femoral nailing systems. The said device comprises a fingerstall with a cannulated guide connected with or without a threaded guide wire. Using this device, surgeons can determine the entry point for the guide wire fast and accurately by tactile hand-eye coordination. After correct entry point is obtained, the guide wire is advanced and the fingerstall-cannulated guide can be easily detached. The device and method can accomplish the following: (1) reduction of the surgery time; (2) reduction of the radiation exposure times, and (3) reduction of the soft tissue damage during surgery. The device is also beneficial for use in fastening together any or all portions of bone surrounding a fracture site.

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Westland, MI, United States of America

Weiping Ren