Shanghai Hengrui Pharmaceutical Co., Ltd.

Jiangsu Hengrui Medicine Company Ltd.

Jinagsu Hengrui Medicine Co., Ltd

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Weimin Wang

Feng He

Weikang Tao

Fanglong Yang

Gang Chen

Xiaodong Li

Peng Cho Tang

Nong Zhang

Hao Zheng

Baolei Zhang

Lin Wu

The present invention relates to an oxopicolinamide derivative, a preparation method therefor and the pharmaceutical use thereof. In particular, the present invention relates to an oxopicolinamide derivative as shown in the general formula (AI), a preparation method therefor and a pharmaceutical composition comprising the derivative, and to the use thereof as a therapeutic agent, in particular as an inhibitor of blood coagulation factor XIa (Factor XIa, FXIa for short) and the use thereof in the preparation of a drug for treating diseases such as thromboembolism, wherein the definition of each substituent in the general formula (AI) is the same as defined in the description. 

Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof

Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed. 

Dihydropteridinone derivatives, preparation process and pharmaceutical use thereof

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Shanghai, China

Weimin Wang