Chinese Academy of Sciences

Yunnan University

East China University of Science and Technology

Weilie Xiao

Hualiang Jiang

Honglin Li

Zhenjiang Zhao

Liumeng Yang

Yongtang Zheng

Hongbin Zhang

Ruirui Wang

Lili Zhu

Jingping Liu

Jianxin Pu

Handong Sun

Lina Quan

Qiao Li

Yanyan Diao

Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease. 

Saponin compound targeting PD-1 and application thereof

Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description. 

Nitrogen-containing biphenyl compounds, pharmaceutical compositions of same, preparation methods and anti-HIV-1 uses thereof

Growing community of inventors

Kunming, China

Weilie Xiao