Endomedix, Inc.

Sustained Nano Systems LLC

The State University of New York

Weiliam Chen

John M Abrahams

Barry M Libin

Jeffrey M Liebmann

Lihui Weng

Libin Barry

Barry Libin

A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.

Radiation sterilization of hypercompresed polymer dosage forms

Radiation sterilization of hypercompressed polymer dosage forms

A pharmaceutical dosage form which comprises a lactide, glycolide or lactide-glycolide polymer, a block polymer of polyglycolide, trimethylene carbonate, poly-caprolactone, and polyethylene oxide that is combined with a peptide or protein therapeutic agent in the form of microparticles which are compressed using a pressure of 50,000 to 350,000 psi.

Hypercompressed pharmaceutical formulations

A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.

Biopolymer system for tissue sealing

A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is 'hyper-compressed' to form a controlled release dispensing device and methods of locally administering a therapeutic agent using said microparticles.

Controlled release implantable dispensing device and method

The present invention features dual network hydrogels that possess the structural, mechanical, and biological properties required of load bearing three-dimensional support structures.

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Mount Sinai, NY, United States of America

Weiliam Chen