Chugai Seiyaku Kabushiki Kaisha

F. Hoffmann-la Roche Ag

Semiconductor Manufacturing International (shanghai) Corporation

Semiconductor Manufacturing International (beijing) Corporation

Fudan University

East China Normal University

WeiLi Zhao

Hiroki Nishii

Lisha Wang

Masayuki Matsushita

Tadakatsu Hayase

Yoshito Nakanishi

Hirosato Ebiike

Masayuki Ohmori

Naoki Taka

Ikumi Hyodo

Toshiyuki Mio

Masami Kochi

Kyoko Takami

YiQi Wang

Jianxiang Cai

Shuang Xu

JingGuo Jia

XiaoFang Yang

Yiwei Li

Shanshan Lu

Guangyu Lin

Xiongwen Zhang

Xiaochun Dong

Kedan Gu

An amino dithioperacid thioester compound, a preparation method therefor, and use thereof. The structural formula of compound is as shown in formula I: wherein m=1-11, X is a nitrogen-containing aliphatic heterocyclic ring, and a nitrogen atom in the aliphatic heterocyclic ring is connected to a carbon atom of a thiocarbonyl group. The compounds disclosed by the invention are found to be capable of relieving muscular atrophy and lipolysis caused by cancer cachexia through in-vivo and in-vitro experiments. The compounds are also capable of obviously relieving weight and food intake reduction caused by cancer cachexia in animal experiments, so that the carbamo(dithioperoxo)thioates compounds have the effect on resisting cancer cachexia, can be applied to the treatment of cancer cachexia and related diseases, and become one kind of ideal cancer cachexia treatment medicament.

Amino dithioperacid thioester compound, preparation method therefor, and use thereof

A semiconductor device and its manufacturing method are presented. The semiconductor device includes a collection region, a base region adjacent to the collection region, an emission region adjacent to the base region, and a doped semiconductor layer on the emission region. The width of the doped semiconductor layer is larger than the width of the emission region, a conductive type (e.g., P-type or N-type) of the doped semiconductor layer is the same as a conductive type of the emission region. In this inventive concept, the width of the doped semiconductor layer on the emission region is larger than the width of the emission region, that equivalently increases the width of the emission region, which in turn increases the DC amplification factor (&#x3b2;) and therefore improves the overall performance of the semiconductor device.

Semiconductor device and manufacture thereof

A method for treating cancer that includes administering a pharmaceutically effective amount of a composition containing a compound represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents a 5- to 10-membered heteroaryl group, or a Caryl group; Rand Rindependently represent H, OH, X, CN, NO, a Chaloalkyl group, a Calkyl group, or the like &#x3c;Rand Rtogether form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group&#x3e;; Rrepresents H, a Calkyl group, a Caryl group, a Calkyl group, or a Chaloalkyl group; and Rrepresents H, X, a Calkyl group, a Chaloalkyl group, OH, CN, NO, or the like. 

Aminopyrazole derivative

A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a Caryl group; Rand Rindependently represent H, OH, X, CN, NO, a Chaloalkyl group, a Calkyl group, or the like &#x3c;Rand Rtogether form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group&#x3e;; Rrepresents H, a Calkyl group, a Caryl group, a Calkyl group, or a Chaloalkyl group; and Rrepresents H, X, a Calkyl group, a Chaloalkyl group, OH, CN, NO, or the like.) 

Growing community of inventors

Shanghai, China

WeiLi Zhao