Baili-bio (chengdu) Pharmaceutical Co., Ltd.

Systimmune, Inc.

Baili-bio Pharmaceutical Co., Ltd.

Sichuan Baili Pharm Co. Ltd

Weili Wan

Yi Zhu

Jie Li

Shi Zhuo

Lan Chen

Yongguo Yu

Yixi Wang

Yiqian Wang

By inserting cysteine (C) into a heavy chain and/or a light chain of a target antibody at specific insertion site, and performing a site-specific conjugation through a free thiol group (&#x2014;SH) from the site-specific inserted cysteine and a linker conjugated with a highly potent small molecule cytotoxin, a cysteine modified antibody-drug conjugate with good homogeneity is provided. The specific insertion sites of cysteine are position 205 and/or position 206 (Kabat numbering scheme) of the light chain of the antibody, and/or position 439 (Kabat numbering scheme) of the heavy chain.

Cysteine modified antibody-drug conjugate and preparation method thereof

Growing community of inventors

Chengdu, China

Weili Wan