Battelle Memorial Institute

Weijun Qian

Richard Dale Smith

Jon Morrell Jacobs

Thomas O Metz

Xuefei Sun

Tujin Shi

David G Camp, Ii

Thomas L Fillmore

Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.

Process for ultra-sensitive quantification of target analytes in complex biological systems

A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.

Method for identifying type I diabetes mellitus in humans

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Richland, WA, United States of America

Weijun Qian