Massachusetts Institute of Technology

Wyeth

Pharm-eco Laboratories, Inc.

Weiheng Wang

Robert Samuel Langer

Daniel Griffith Anderson

Adel M Moussa

Jeremy Ian Levin

Yang-I Lin

Jerauld S Skotnicki

Yizhou Dong

Omid Veiseh

Eric Andrew Appel

Frank Eldridge Lovering

Jurjus Jurayj

George Diamantidis

Matthew J Webber

Reem M Haider

Zhong Li

Kaapjoo Park

Jeffrey Scott Condon

Benjamin C Tang

Heather Taft

Kun Xue

HaeSuk Suh

Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

Polymers, hydrogels, and uses thereof

This invention provides compounds of Formula I, having the structure: that are useful in treating diseases or disorders mediated by TNF-&#x3b1;, such as arthritis (rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, osteoarthritis etc), tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection, ankylosing spondylitis, psoriasis, sepsis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, asthma, idiopathic pulmonary fibrosis, vasculitis, systemic lupus erythematosus, irritable bowel syndrome, acute coronary syndrome, hepatitis C, cachexia, COPD, stroke or type 2 diabetes, and for alleviation of symptoms thereof. The invention further provides methods for use of the compounds.

Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase

The present invention is a method of preparing a 3-aryl-1-indanamine represented by structural formula I:

Synthesis of 3-aryl-1-indanamines

Growing community of inventors

Bedford, MA, United States of America

Weiheng Wang