Hutchison Medipharma Enterprises Limited

Hutchison Medipharma Limited

Nutrition Science Partners Limited

Weihan Zhang

Xiaoqiang Yan

Wei-Guo Su

Jifeng Duan

Yu Cai

Yumin Cui

Yongxin Ren

Tao Wang

Hong Jia

Zhiming Ma

Yang Sai

Haibin Yang

Weiguo Su

Wenji Li

Zhenping Wu

Zhenping Tian

Jiangyong Shao

Bo Tong Liu

Lei Jiang

Wei Deng

Guangxiu Dai

Jinshui Li

Jeff Duan

Zhiyong Yu

Ke Pan

Xiong Li

Huaqing Cai

Zhilong Weng

Hongqiang Wang

Jianrong Hong

Jifen Duan

The present invention relates to novel amide compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein the definition of each symbol is as described in the description.

Amide compounds and uses thereof

Disclosed herein are extracts ofhaving highly concentrated active ingredients, preparation methods and medical use for treating autoimmunity and inflammatory disease.

Extracts of, methods for preparation and use thereof

This disclosure provides novel imidazopyridazine compounds of formula (I) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing them, a process for preparing them, and their practical effect in inhibiting PIK and potential use in treating a disease responsive to inhibition of PIK, for example, an inflammatory disease, autoimmune disease or cancer. 

Imidazopyridazine compounds and their use

The present invention relates to novel pyrimidine and pyridine compounds of formula (I) or a pharmaceutical acceptable salt thereof, wherein R, R, R, R, R, X, Y and G are as defined in the description, to pharmaceutical compositions containing them, a process for preparing them, and their use in therapy of a disease responsive to inhibition of FGFR, for example, cancer.

Pyrimidine and pyridine compounds and their usage

Provided are certain fused heteroaryls, compositions thereof and methods of use therefor.

Fused heteroaryls and their uses

Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).

Quinazoline compounds

Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

A compound of the following formula: wherein R, R, R, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Pyrimidine derivatives

An extract ofextract containing andrographolide, 14-deoxyandrographolide, 14-deoxy-11,12-dehydroandrographolide, neoandrographolide, polysacchorides, and flavanoids. Also disclosed is a pharmaceutical composition containing such an extract and its use for treating inflammatory bowel disease.

[object Object]

Quinazoline derivatives of the following formula: wherein R, R, R, R, R, R, R, R, R, R, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Use of substituted quinazoline compounds in treating age-related macular degeneration

Quinazoline derivatives of the following formula: wherein R, R, R, R, R, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.

Quinazoline derivatives

Use of substituted quinazoline compounds in treating angiogenesis-related diseases

Growing community of inventors

Shanghai, China

Weihan Zhang