Yeda Research and Develpment & Co. Ltd

Weifeng Lin

Ronit Goldberg

Jacob Klein

Jasmine Seror

Reut Mashiach

Sabrina Jahn

A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

Lipid analogs and liposomes comprising same

A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises:

Liposomic drug-delivery vehicles

A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

Growing community of inventors

Rehovot, Israel

Weifeng Lin